PINK1 and Parkin flag Miro to direct mitochondrial traffic.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22078873.
- Also identified by DOI 10.1016/j.cell.2011.10.028.
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Abstract
The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PINK1 and Parkin also regulate mitochondrial trafficking and quarantine damaged mitochondria by severing their connection to the microtubule network.