Feedback on fat: p62-mTORC1-autophagy connections.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22078874.
- Also identified by DOI 10.1016/j.cell.2011.10.021 and PMC identifier 3290994.
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Abstract
Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Autophagy
- Homeostasis
- Inflammation
- Multiprotein Complexes
- Transcription Factors