Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis.
Where this comes from
- Record sourced from PubMed, PMID 22083636.
- Also identified by DOI 10.1038/ki.2011.300 and PMC identifier 4316679.
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Abstract
Fibrosis can be considered as wound healing that never ceases, and activated fibroblasts (myofibroblasts) probably play a critical role in this unabated tissue repair process. In the setting of renal fibrosis, two central questions remain unanswered: Where do activated myofibroblasts come from; and what mechanism or mechanisms keep them activated? The study by Chen and colleagues addresses the role of platelet-derived growth factor receptor (PDGFR) signaling in the activation of myofibroblasts.
Medical subject headings
- Fibrosis
- Kidney Diseases
- Myofibroblasts
- Pericytes
- Receptors, Platelet-Derived Growth Factor
- Reperfusion Injury
- Ureteral Obstruction