Update on ischemia-reperfusion injury for the plastic surgeon: 2011.

Wang, Wei Z; Baynosa, Richard C; Zamboni, William A · Plast Reconstr Surg · 2011

review · Level V

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Abstract

Ischemia-reperfusion injury occurs when tissue is reperfused following a prolonged period of ischemia. It is a subject of interest to plastic surgeons involved in replantation, free tissue transfer, and composite tissue allotransplantation, as it can have a significant impact on the overall success of these procedures. The purpose of this article is to review the recent progress in the investigation of ischemia-reperfusion injury in skeletal muscle and skin and to highlight the potential clinical implications of therapeutic interventions aimed at reducing ischemia-reperfusion injury.

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