Ribosomal RNA evidence of ocular Chlamydia trachomatis infection following 3 annual mass azithromycin distributions in communities with highly prevalent trachoma.

Keenan, Jeremy D; Ayele, Berhan; Gebre, Teshome; Moncada, Jeanne; Stoller, Nicole E; Zhou, Zhaoxia; Porco, Travis C; McCulloch, Charles E et al. · Clin Infect Dis · 2012

cross_sectional · Level IV

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Abstract

Twelve trachoma-hyperendemic communities were treated with 3 annual mass azithromycin distributions. Children aged 0-9 years were monitored 1 year following the third treatment. An RNA-based test detected ocular chlamydial infection in more children than did a DNA-based test (6.9% vs 4.2%), and in a larger number of communities (8 vs 7).

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