Drug release from electric-field-responsive nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22111891.
- Also identified by DOI 10.1021/nn203430m and PMC identifier 3489921.
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Abstract
We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric field. This approach represents a novel interactive drug delivery system that can show an externally tailored release profile with an excellent spatial, temporal, and dosage control.
Medical subject headings
- Delayed-Action Preparations
- Nanocapsules
- Pharmaceutical Preparations
- Polymers