Anti-/Propsychotic drug signaling via heteromeric GPCRs--a balancing act?
editorial · Level V
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- Record sourced from PubMed, PMID 22118451.
- Also identified by DOI 10.1016/j.cell.2011.11.012.
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Abstract
In this issue, Fribourg et al. provide insight into a molecular basis of psychosis. They reveal that a heteromeric complex formed by the G protein-coupled receptors (GPCRs) for glutamate and serotonin is a convergent site for the activity of anti- or propsychotic drugs, opening a possibility for new therapeutic strategies for schizophrenia.