Kinesins lead aging microtubules to catastrophe.
basic_science · Level V
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- Record sourced from PubMed, PMID 22118452.
- Also identified by DOI 10.1016/j.cell.2011.11.011.
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Abstract
The ability of growing microtubules to undergo catastrophes--abrupt switches from growth to shortening--is one of the key aspects of microtubule dynamics important for shaping cellular microtubule arrays. Gardner et al. show that catastrophes occur at a microtubule age-dependent rate and that depolymerizing kinesins can affect this process in fundamentally different ways.