Contribution of Ih to LTP, place cells, and grid cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 22118453.
- Also identified by DOI 10.1016/j.cell.2011.11.005.
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Abstract
The brain's grid and place cells, which contribute to spatial representations of the external environment, are thought to be modulated by the hyperpolarization-activated cation current (I(h)). Giocomo et al. and Hussaini et al. now provide new insights into these cells' unique activity patterns by studying transgenic mice lacking I(h).