Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks.
case_report · Level V
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- Record sourced from PubMed, PMID 22120338.
- Also identified by DOI 10.1016/j.wneu.2011.07.006.
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Abstract
Epileptic myoclonus is generally treated by valproate monotherapy, and this therapy has confirmed efficacy. However, almost 30% of patients with juvenile myoclonic epilepsy (JME) are valproate-resistant. A 23-year-old man with a diagnosis of JME had resistance to multiple antiepileptic drugs (AEDs). Stepwise synchronization of bilateral spikes on electroencephalography (EEG) was found shortly before the clinical myoclonus. The anterior two thirds of the corpus callosum were divided. Desynchronization of spikes by the corpus callosotomy arrested the patient's myoclonus. Interhemispheric recruitment of epileptic spikes through the corpus callosum may induce synchronization of spikes and myoclonus.
Medical subject headings
- Anticonvulsants
- Anticonvulsants/therapeutic use
- Cognition Disorders
- Cognition Disorders/etiology
- Cognition Disorders/physiopathology
- Corpus Callosum
- Corpus Callosum/physiopathology
- Corpus Callosum/surgery
- Cortical Synchronization
- Cortical Synchronization/physiology
- Drug Resistance
- Electroencephalography
- Functional Laterality
- Functional Laterality/physiology
- Humans
- Isoxazoles
- Isoxazoles/therapeutic use
- Magnetic Resonance Imaging
- Male
- Myoclonus
- Myoclonus/etiology
- Myoclonus/physiopathology
- Myoclonus/surgery
- Neurosurgical Procedures
- Seizures
- Seizures/physiopathology
- Syncope
- Syncope/etiology
- Valproic Acid
- Valproic Acid/therapeutic use
- Young Adult
- Zonisamide