Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22124129.
- Also identified by DOI 10.1093/infdis/jir688.
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Abstract
Toxin A has historically been regarded as the primary virulence determinant in Clostridium difficile infection, but naturally occurring toxin A-negative, toxin B-positive (A-/B+) C. difficile strains are known to be virulent. To determine the role of toxin B in these strains, we immunized hamsters with a toxoid prepared from purified toxin B to determine whether they would be protected from lethal challenge with an A-/B+ strain of C. difficile.
Medical subject headings
- Bacterial Proteins
- Bacterial Toxins
- Clostridioides difficile
- Clostridium Infections
- Enterotoxins
- Toxoids
- Vaccination
- Virulence Factors