Sugars and alcohol: IgA-associated renal diseases in alcoholic cirrhosis.
other · Level V
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- Record sourced from PubMed, PMID 22126980.
- Also identified by DOI 10.1038/ki.2011.302.
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Abstract
Tissandié and colleagues report in this issue on their studies of IgA1 glycosylation and biological activities of IgA1-containing circulating immune complexes in patients with alcoholic cirrhosis who developed secondary renal disease with IgA deposits, secondary IgA nephropathy. Their seminal findings demonstrate abnormal glycosylation of IgA1 N-linked as well as O-linked glycans. Furthermore, their work reveals unique biological properties of immune complexes in these patients as compared with those in patients with primary IgA nephropathy.
Medical subject headings
- Antigen-Antibody Complex
- Antigens, CD
- Glomerulonephritis, IGA
- Immunoglobulin A
- Immunoglobulin G
- Kidney
- Liver Cirrhosis, Alcoholic
- Receptors, Fc