Optically mapping multiple bacterial genomes simultaneously in a single run.
basic_science · Level V
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- Record sourced from PubMed, PMID 22132087.
- Also identified by DOI 10.1371/journal.pone.0027085 and PMC identifier PMC2373919.
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Abstract
Optical mapping of bacterial chromosomes provides an unambiguous low-resolution sequence scaffold of the entire chromosome. In comparison to some techniques, such as pulse field gel electrophoresis, cost and throughput limit the application of this technique outside of genome finishing. We have demonstrated the production of multiple bacterial maps using a single set of consumables; this significantly reduces the time and expense of map production.