miRNA processing and human cancer: DICER1 cuts the mustard.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22133720.
- Also identified by DOI 10.1126/scitranslmed.3002493.
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Abstract
Numerous studies have implicated microRNAs (miRNAs) in cancer initiation and progression. In contrast, only recently has attention been focused on the pathway that generates these regulatory molecules. The identification of neoplasia-associated germline mutations in DICER1 has focused translational research on components of the miRNA processing pathway. Deciphering of the many links between miRNA processing perturbations and cancer will likely provide insights into mechanisms of cancer control.
Medical subject headings
- DEAD-box RNA Helicases
- MicroRNAs
- Neoplasms
- RNA Processing, Post-Transcriptional
- Ribonuclease III