Haploid embryonic stem cells and the dominance of recessive traits.
basic_science · Level V
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- Record sourced from PubMed, PMID 22136917.
- Also identified by DOI 10.1016/j.stem.2011.11.006.
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Abstract
Diploidy, though essential for normal development, is a foil to geneticists. Two recent studies (Elling et al., 2011, this issue of Cell Stem Cell; Leeb and Wutz, 2011, Nature), report the isolation of haploid pluripotent mouse ESCs, thus enabling efficient functional screening for genes involved in diverse cellular and developmental processes.