Blood cells need glia, too: a new role for the nervous system in the bone marrow niche.
review · Level V
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- Record sourced from PubMed, PMID 22136920.
- Also identified by DOI 10.1016/j.stem.2011.11.016.
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Abstract
Regulation of hematopoietic stem cell (HSC) dormancy by specific cell types in the hematopoietic niche remains poorly understood. Yamazaki et al. (2011) now report that nerve-associated nonmyelinating Schwann cells activate TGF-β to maintain dormant HSCs, suggesting that glia are novel players in the bone marrow niche.