Induced neuronal cells: how to make and define a neuron.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22136927.
- Also identified by DOI 10.1016/j.stem.2011.11.015 and PMC identifier 4377331.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated. In this review, we summarize the most recent developments in this nascent field and suggest criteria to help define and categorize iN cells that take into account the complexity of neuronal identity.
Medical subject headings
- Cell Differentiation
- Neurons