Diseases in a dish: modeling human genetic disorders using induced pluripotent cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22146428.
- Also identified by DOI 10.1038/nm.2504.
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Abstract
The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.
Medical subject headings
- Disease Models, Animal
- Genetic Diseases, Inborn
- Induced Pluripotent Stem Cells