Of mice and men: not ExAKTly the same?
basic_science · Level V
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- Record sourced from PubMed, PMID 22152300.
- Also identified by DOI 10.1016/j.cmet.2011.11.009.
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Abstract
The serine-threonine protein kinase Akt2, also known as PKBβ, has been shown to regulate glucose and lipid metabolism in animal models. In a recent study published in Science, Hussain et al. (2011) report that in human subjects an activating mutation of Akt2 leads to hypoglycemia and, unexpectedly, asymmetric overgrowth.