Lock and key to transcription: σ-DNA interaction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22153066.
- Also identified by DOI 10.1016/j.cell.2011.11.033.
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Abstract
How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these two processes are interconnected.