A partner evokes latent differences between Hox proteins.
basic_science · Level V
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- Record sourced from PubMed, PMID 22153067.
- Also identified by DOI 10.1016/j.cell.2011.11.046.
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Abstract
Hox transcription factors bind highly related DNA sequences in vitro, yet they regulate different genes and play distinct roles in anterior-posterior patterning in animals. Slattery et al. report that a common cofactor, Exd, accentuates latent sequence specificities of all eight Hox proteins and directs binding to relevant sites across the genome.