Evaluation of the correlation between genetic damage and occupational chromate exposure through BNMN frequencies.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 22157804.
- Also identified by DOI 10.1097/JOM.0b013e31823d86b4.
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Abstract
To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage. There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted. The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models. The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance.
Medical subject headings
- Air Pollutants, Occupational
- Chromates
- DNA Damage
- Environmental Monitoring
- Micronuclei, Chromosome-Defective
- Occupational Exposure