Toxic epidermal necrolysis: review of pathogenesis and management.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22169256.
- Also identified by DOI 10.1016/j.jaad.2011.09.029.
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Abstract
Toxic epidermal necrolysis (TEN) is a severe cutaneous drug reaction with a mortality rate of approximately 30%. The hallmark of TEN is widespread epidermal sloughing due to keratinocyte apoptosis. Multiple genetic associations between TEN and specific ethnic populations have been determined. The pathophysiology of TEN has yet to be fully elucidated; however, current pathogenic models implicate Fas ligand, granulysin, and reactive oxygen species. The value of current therapies, such as intravenous immunoglobulin and corticosteroids, remains under evaluation.
Medical subject headings
- Stevens-Johnson Syndrome