Does PTEN loss impair DNA double-strand break repair by homologous recombination?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22179663.
- Also identified by DOI 10.1158/1078-0432.CCR-11-3131 and PMC identifier 4151559.
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Abstract
The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity.
Medical subject headings
- Gene Deletion
- PTEN Phosphohydrolase
- Prostatic Neoplasms
- Rad51 Recombinase