Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22180323.
- Also identified by DOI 10.1002/adma.201103458.
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Abstract
A novel redox responsive controlled drug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/β-CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles. The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed.
Medical subject headings
- Antineoplastic Agents
- Drug Carriers
- Intracellular Space
- Magnetite Nanoparticles