A neuroprotective role for the DNA damage checkpoint in tauopathy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22181010.
- Also identified by DOI 10.1111/j.1474-9726.2011.00778.x.
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Abstract
ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimer's disease. Surprisingly, checkpoint attenuation potently increases neurodegeneration through aberrant cell cycle re-entry of postmitotic neurons. These data suggest an unexpected neuroprotective role for the DNA damage checkpoint in tauopathies.
Medical subject headings
- Cell Cycle Checkpoints
- DNA Damage
- Tauopathies