The first Plasmodium vivax relapses of life are usually genetically homologous.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 22194628.
- Also identified by DOI 10.1093/infdis/jir806 and PMC identifier 3266132.
- Licence recorded as CC BY-NC.
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Abstract
In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to the initial infection in 13 of 20 (65%) mothers compared with 5 of 24 (21%) infants (P = .02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations.
Medical subject headings
- DNA, Protozoan
- Malaria, Vivax
- Microsatellite Repeats
- Plasmodium vivax