Airway cells from atopic asthmatic patients exposed to ozone display an enhanced innate immune gene profile.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 22196529.
- Also identified by DOI 10.1016/j.jaci.2011.11.007 and PMC identifier 3254026.
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Abstract
This study identifies transcriptional phenotypes of sputum samples from normal volunteers and atopic asthmatics exposed to ozone. Network analyses suggest that asthmatics elevate immune signaling following oxidative stress, while nonasthmatics attempt to mitigate the ozone-induced response.
Medical subject headings
- Asthma
- Immunity, Innate
- Oxidants, Photochemical
- Ozone