Food for thought: linking caloric intake to behavior via sirtuin activity.
basic_science · Level V
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- Record sourced from PubMed, PMID 22196720.
- Also identified by DOI 10.1016/j.cell.2011.11.052.
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Abstract
Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior via monoamine signaling and that changes in this pathway might contribute to human affective disorders.