Transcription and mRNA stability: parental guidance suggested.
basic_science · Level V
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- Record sourced from PubMed, PMID 22196721.
- Also identified by DOI 10.1016/j.cell.2011.12.002.
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Abstract
The level of an mRNA within a cell depends on both its rate of synthesis and rate of decay. Now, independent studies by Bregman et al. and Trcek et al. provide evidence that these two processes are integrated. They show that transcription factors and DNA promoters can directly influence the relative stability of transcripts that they produce.