DNA origami nanopores.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22196850.
- Also identified by DOI 10.1021/nl204098n.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our experiments, single artificial nanopores based on DNA origami are repeatedly inserted in and ejected from solid-state nanopores with diameters around 15 nm. We show that these hybrid nanopores can be employed for the detection of λ-DNA molecules. Our approach paves the way for future development of adaptable single-molecule nanopore sensors based on the combination of solid-state nanopores and DNA self-assembly.
Medical subject headings
- DNA
- Molecular Probe Techniques
- Nanostructures
- Ultrafiltration