Increasing potential of HER3 signaling in colon cancer progression and therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22205688.
- Also identified by DOI 10.1158/1078-0432.CCR-11-3143.
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Abstract
HER3 protein levels at the cancer cell plasma membrane are directly correlated with reduced survival in patients with colorectal cancer. In colorectal cancer cells, HER3 blockade restricted cellular growth (G(2)-M arrest), survival, migration, and invasion, and potentiated the chemotherapeutic effect of 5-FU, supporting strategies that target HER3 in subsets of patients with colorectal cancer.
Medical subject headings
- Antineoplastic Agents
- Colonic Neoplasms
- Protein Kinase Inhibitors
- Receptor, ErbB-3