Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22213347.
- Also identified by DOI 10.1002/adma.201103828.
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Abstract
The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.
Medical subject headings
- Collagen
- Durapatite
- Mesenchymal Stem Cells
- Nanostructures
- Osteogenesis
- Tissue Scaffolds
- Transfection