Congenital diaphragmatic hernia: impact of prostanoids in the perioperative period.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 2221977.
- Also identified by PMC identifier 1792123.
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Abstract
A prospective study of 10 neonates with congenital diaphragmatic hernia and five controls to determine the importance of prostanoid concentrations perioperatively and the relation with persistent pulmonary hypertension (PPH) is reported. In neonates with congenital diaphragmatic hernia postoperative concentrations of the vasoconstrictor thromboxane B2 rose significantly and were higher during episodes of PPH; this rise may provoke PPH and subsequent right to left shunting.
Medical subject headings
- 6-Ketoprostaglandin F1 alpha
- Hernias, Diaphragmatic, Congenital
- Persistent Fetal Circulation Syndrome
- Thromboxane B2