Kinetically assembled nanoparticles of bioactive macromolecules exhibit enhanced stability and cell-targeted biological efficacy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22223224.
- Also identified by DOI 10.1002/adma.201103348 and PMC identifier 3495129.
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Abstract
Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor-level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low-density lipoprotein (oxLDL) uptake in inflammatory cells.
Medical subject headings
- Macromolecular Substances
- Nanoparticles
- Nanotechnology