Chimeric primates: embryonic stem cells need not apply.
basic_science · Level V
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- Record sourced from PubMed, PMID 22225613.
- Also identified by DOI 10.1016/j.cell.2011.12.016.
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Abstract
In this issue, Tachibana et al. report the generation of the first chimeras from a nonhuman primate, the rhesus monkey. Unlike mice, rhesus chimeras fail to form when embryonic stem cells are injected into blastocysts. Instead, chimera formation is achieved by aggregation of several four-cell embryos.