Power surge: supporting cells "fuel" cancer cell mitochondria.
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- Record sourced from PubMed, PMID 22225869.
- Also identified by DOI 10.1016/j.cmet.2011.12.011.
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Abstract
An emerging paradigm in tumor metabolism is that catabolism in host cells "fuels" the anabolic growth of cancer cells via energy transfer. A study in Nature Medicine (Nieman et al., 2011) supports this; they show that triglyceride catabolism in adipocytes drives ovarian cancer metastasis by providing fatty acids as mitochondrial fuels.