Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22226782.
- Also identified by DOI 10.1053/j.gastro.2011.12.042 and PMC identifier 3321090.
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Abstract
More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
Medical subject headings
- Carcinoma in Situ
- Carcinoma, Pancreatic Ductal
- Mutation
- Pancreatic Neoplasms