Telomerase at the center of collapsing glomerulopathy.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22227662.
- Also identified by DOI 10.1038/nm.2602 and PMC identifier 4114573.
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Abstract
Collapsing glomerulopathy, the classic kidney lesion in HIV-associated nephropathy, is characterized by the closure of glomerular capillary loops and epithelial cell proliferation. A new study shows that upregulation of TERT, the reverse transcriptase component of telomerase, in podocytes, the key filtration cells in the kidney, plays a major part in the development of this condition by activating Wnt signaling (pages 111–119).
Medical subject headings
- AIDS-Associated Nephropathy
- Kidney
- Kidney Glomerulus
- Podocytes
- Telomerase
- Wnt Signaling Pathway