Recurrent severe exacerbations in early life and reduced lung function at school age.

O'Brian, Amy L; Lemanske, Robert F; Evans, Michael D; Gangnon, Ronald E; Gern, James E; Jackson, Daniel J · J Allergy Clin Immunol · 2012

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Abstract

Severe wheezing exacerbations during the preschool years, a critical time in lung growth and development, may lead to airway damage and remodeling. Our study linked these events to a partially reversible reduction in lung function present at school age.

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