Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 22238165.
- Also identified by DOI 10.1093/cid/cir926 and PMC identifier 3275762.
- Licence recorded as CC BY-NC.
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Abstract
Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.
Medical subject headings
- Meningitis, Pneumococcal
- Streptolysins