RIBER/DIBER: a software suite for crystal content analysis in the studies of protein-nucleic acid complexes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22238259.
- Also identified by DOI 10.1093/bioinformatics/bts003 and PMC identifier 3307108.
- Licence recorded as CC BY-NC.
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Abstract
Co-crystallization experiments of proteins with nucleic acids do not guarantee that both components are present in the crystal. We have previously developed DIBER to predict crystal content when protein and DNA are present in the crystallization mix. Here, we present RIBER, which should be used when protein and RNA are in the crystallization drop. The combined RIBER/DIBER suite builds on machine learning techniques to make reliable, quantitative predictions of crystal content for non-expert users and high-throughput crystallography.
Medical subject headings
- Artificial Intelligence
- DNA
- DNA-Binding Proteins
- RNA
- RNA-Binding Proteins
- Software