Mouse models of cancer: does the strain matter?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22257951.
- Also identified by DOI 10.1038/nrc3206 and PMC identifier 6309955.
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Abstract
Mouse models are indispensible tools for understanding the molecular basis of cancer. However, despite the invaluable data provided regarding tumour biology, owing to inbreeding, current mouse models fail to accurately model human populations. Polymorphism is the essential characteristic that makes each of us unique humans, with different disease susceptibility, presentation and progression. Therefore, as we move closer towards designing clinical treatment that is based on an individual's unique biological makeup, it is imperative that we understand how inherited variability influences cancer phenotypes, how it can confound experiments and how it can be exploited to reveal new truths about cancer biology.
Medical subject headings
- Disease Models, Animal
- Neoplasms, Experimental