The contribution of bone to whole-organism physiology.
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- Record sourced from PubMed, PMID 22258610.
- Also identified by DOI 10.1038/nature10763 and PMC identifier PMC2836724.
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Abstract
The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.