Detection of molluscum contagiosum virus (MCV) DNA in the plasma of an immunocompromised patient and possible reduction of MCV DNA with CMX-001.
case_report · Level V
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- Record sourced from PubMed, PMID 22262788.
- Also identified by DOI 10.1093/infdis/jir853 and PMC identifier 3274371.
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Abstract
Molluscum contagiosum virus (MCV) is a poxvirus that causes localized papules in healthy persons. We evaluated a woman with severe immunodeficiency and disseminated MCV. During treatment with CMX-001, an antiviral with activity against other poxviruses, MCV DNA was detected in 20% of plasma samples. When the patient was not receiving CMX-001, MCV DNA was detected in 50% of samples. We also noted improvement in warts on her fingers during CMX-001 therapy. Although MCV is caused by direct inoculation of virus into skin in healthy persons, in a severely immunocompromised person MCV DNA was present in blood and may spread by viremia.
Medical subject headings
- Antiviral Agents
- Cytosine
- DNA, Viral
- Molluscum Contagiosum
- Molluscum contagiosum virus
- Organophosphonates