Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22265401.
- Also identified by DOI 10.1016/j.cell.2012.01.003 and PMC identifier 3336960.
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Abstract
The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.
Medical subject headings
- Aging
- Epigenomics
- Rejuvenation