Tailoring 3D single-walled carbon nanotubes anchored to indium tin oxide for natural cellular uptake and intracellular sensing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22268573.
- Also identified by DOI 10.1021/nl203780d and PMC identifier 3542912.
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Abstract
The ability to monitor intracellular events in real time is paramount to advancing fundamental biological and clinical science. We present the first demonstration of a direct interface of vertically aligned single-walled carbon nanotubes (VASWCNTs) with eukaryotic cells, RAW 264.7 mouse macrophage cell line. The cells were cultured on indium tin oxide with VASWCNTs. VASWCNTs entered the cells naturally without application of any external force and were shown to sense the intracellular presence of a redox active moiety, methylene blue. The technology developed provides an alluring platform to enable electrochemical study of an intracellular environment.
Medical subject headings
- Biosensing Techniques
- Macrophages
- Nanotubes, Carbon
- Tin Compounds