Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 22270436.
- Also identified by DOI 10.1097/AOG.0b013e31822cecf7 and PMC identifier 3470464.
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Abstract
Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity. A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate. Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility.
Medical subject headings
- Leptin
- Lipodystrophy
- Pregnancy Complications