Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22270723.
- Also identified by DOI 10.1038/nm.2608 and PMC identifier 3274627.
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Abstract
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression.
Medical subject headings
- DNA Methylation
- Dinoprostone
- Intestinal Neoplasms