TurboKnot: rapid prediction of conserved RNA secondary structures including pseudoknots.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22285566.
- Also identified by DOI 10.1093/bioinformatics/bts044 and PMC identifier 3307117.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Many RNA molecules function without being translated into proteins, and function depends on structure. Pseudoknots are motifs in RNA secondary structures that are difficult to predict but are also often functionally important. TurboKnot is a new algorithm for predicting the secondary structure, including pseudoknotted pairs, conserved across multiple sequences. TurboKnot finds 81.6% of all known base pairs in the systems tested, and 75.6% of predicted pairs were found in the known structures. Pseudoknots are found with half or better of the false-positive rate of previous methods.
Medical subject headings
- Algorithms
- Nucleic Acid Conformation
- RNA, Untranslated